A rare intergenerational collaboration that feels like it was conducted on truly equal footing, this meeting of two art-rock titans — the indefatigable Byrne and alien-pixie superwoman Annie Clark — finds an amiable synthesis of two aesthetically aligned but highly distinctive voices. Love This Giant (4AD) is predictably off-kilter, full of self-consciously stiff musical settings and capricious rhythmic switch-ups, hopscotching lyrically between domesticity and myth, paleolithic prehistory and urban modernity. Still, the album winds up hugely likable and almost human in its heartfelt, whimsical eccentricity. It’s also rife with dense, meaty brass-band counterpoint, navigating everything from jagged party funk to hymnlike chorales. Live, expect a spirited, eight-strong horn section, plenty of playful choreography and generous side-servings from each artists’ back catalog. (How perfect would it be for them to segue from “Cruel” to “Road to Nowhere”?) Just don’t show up late — there’s no opener.

Thu., Sept. 27, 8 p.m., $52-$79.75, Tower Theatre, 69th and Ludlow streets, Upper Darby, 610-352-2887, livenation.com.